SKU: 16-0415
{"url":"https://www.epicypher.com/products/nucleosomes/modified-designer-nucleosomes-dnucs/heterotypic-h3k4me3-h3k9-14-18ac-recombinant-nucleosome-biotinylated","add_this":[{"service":"facebook","annotation":""},{"service":"email","annotation":""},{"service":"print","annotation":""},{"service":"twitter","annotation":""},{"service":"linkedin","annotation":""}],"gtin":null,"id":1168,"bulk_discount_rates":[],"can_purchase":true,"meta_description":"Heterotypic nucleosomes, also referred to as “asymmetric nucleosomes,” contain sister histones with distinct histone variants and/or post-translational modifications (PTMs). Heterotypic nucleosomes represent an additional layer of the histone code, acting as substrates for multivalent reader proteins, participating in PTM crosstalk mechanisms, and influencing reader protein binding affinity through varying local target concentration. Recombinant heterotypic nucleosomes are useful for studying chromatin dynamics and transcriptional regulation. Heterotypic [H3K4me3 • H3K9,14,18ac] Recombinant Nucleosome, Biotinylated is a fully defined semi-synthetic nucleosome containing combinatorial PTMs in both cis and trans whereby one histone H3 is trimethylated at lysine four while the other is acetylated at lysines 9, 14, and 18. H3 hyperacetylation in cis (e.g. H3K9,14,18ac) increases tail accessibility for H3K4 methyl writers such as the methyltransferase MLL1, emphasizing the role of PTM crosstalk and heterotypic nucleosomes in chromatin regulatory mechanisms.","category":["Nucleosomes","Nucleosomes/Modified Designer Nucleosomes (dNucs™)"],"AddThisServiceButtonMeta":"","main_image":{"data":"https://cdn11.bigcommerce.com/s-y9o92/images/stencil/{:size}/products/1168/1240/Heterotypic_Nuc_white__85489.1723235678.png?c=2","alt":"Heterotypic [H3K4me3 • H3K9,14,18ac] Recombinant Nucleosome, Biotinylated"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=1168","shipping":{"calculated":true},"num_reviews":0,"weight":"0.00 LBS","custom_fields":[{"id":"1333","name":"Pack Size","value":"25 µg"}],"sku":"16-0415","description":"<div class=\"product-general-info\">\n <ul class=\"product-general-info__list-left\">\n <li class=\"product-general-info__list-item\">\n <strong>Species: </strong>Human\n </li>\n <li class=\"product-general-info__list-item\">\n <strong>Source: </strong><i>E. coli</i> & synthetic DNA\n </li>\n </ul>\n <ul class=\"product-general-info__list-right\">\n <li class=\"product-general-info__list-item\">\n <strong>Tag: </strong>Biotinylated\n </li>\n <li class=\"product-general-info__list-item\">\n <strong>Molecular Weight: </strong>199,815 Da\n </li>\n </ul>\n</div>\n<div class=\"service_accordion product-droppdown\">\n <div class=\"container\">\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel current\">\n <h3 class=\"sub-title1\">Description</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description-specific\">\n <p>\n Heterotypic nucleosomes, also referred to as “asymmetric nucleosomes,” contain sister histones with distinct\n histone variants and/or post-translational modifications (PTMs). In homotypic nucleosomes, or “symmetric\n nucleosomes,” each pair of sister histones bears the same PTM, set of PTMs, or histone variant.\n Histone-modifying enzymes, chromatin remodelers, and histone chaperones differentially modify sister\n histones or exchange unique histone variants to form heterotypic nucleosomes. Heterotypic nucleosomes have\n been found at promoters of developmental genes in undifferentiated embryonic stem cells and transcription\n start sites (TSSs) of approximately half of the genes in budding yeast [1]. Heterotypic nucleosomes\n represent an additional layer of the histone code, acting as substrates for multivalent reader proteins,\n participating in PTM crosstalk mechanisms, and influencing reader protein binding affinity through varying\n local target concentration. Recombinant heterotypic nucleosomes are useful for studying chromatin dynamics\n and transcriptional regulation.\n </p>\n <p>\n Heterotypic [H3K4me3 • H3K9,14,18ac] Recombinant Nucleosome, Biotinylated is a fully defined semi-synthetic\n nucleosome containing combinatorial PTMs in both <em>cis</em> and <em>trans</em> whereby one histone H3 is\n trimethylated at\n lysine four while the other is acetylated at lysines 9, 14, and 18. [H3K4me3 • H3K9,14,18ac] nucleosome\n consists of 147 base pairs of 601 sequence DNA [2] wrapped around an octamer of core histone proteins (two\n each of H2A, H2B, H3.2, and H4) to form a nucleosome, the basic repeating unit of chromatin. The DNA\n contains a 5’ biotin-TEG group, and histone H3.2 has a Cys to Ala substitution at position 110. H3\n hyperacetylation in <em>cis</em> (e.g. H3K9,14,18ac) increases tail accessibility for H3K4 methyl writers\n such as the\n methyltransferase MLL1, emphasizing the role of PTM crosstalk and heterotypic nucleosomes in chromatin\n regulatory mechanisms [3].\n </p>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel current\">\n <h3 class=\"sub-title1\">Validation Data</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description-specific\">\n <section class=\"image-picker\">\n <div class=\"image-picker__left\">\n <div class=\"image-picker__main-content_active image-picker__main-content\">\n <div class=\"image-picker__header-content\">\n <button class=\"image-picker__left-arrow\">\n <svg class=\"image-picker__svg-left\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M16.67 0l2.83 2.829-9.339 9.175 9.339 9.167-2.83 2.829-12.17-11.996z\" />\n </svg>\n </button>\n <a href=\"/content/images/products/nucleosomes/16-0415-protein-gel.jpeg\" target=\"_blank\"\n class=\"image-picker__main-image-link\"><img alt=\"16-0415-protein-gel\"\n src=\"/content/images/products/nucleosomes/16-0415-protein-gel.jpeg\"\n class=\"image-picker__main-image\" />\n <span class=\"image-picker__main-image-caption\">(Click to enlarge)</span></a>\n <button class=\"image-picker__right-arrow\">\n <svg class=\"image-picker__svg-right\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M7.33 24l-2.83-2.829 9.339-9.175-9.339-9.167 2.83-2.829 12.17 11.996z\" />\n </svg>\n </button>\n </div>\n <p>\n <span class=\"image-picker__span-content\"><strong>Figure 1: Protein gel data</strong><br />\n Coomassie stained SDS-PAGE gel of proteins in heterotypic [H3K4me3 • H3K9,14,18ac] nucleosome (1 µg)\n demonstrates the purity of histones in the preparation. Sizes of molecular weight markers and\n positions of the core histones (H2A, H2B, H3K4me3 • H3K9,14,18ac, and H4) are indicated.\n </span>\n </p>\n </div>\n <div class=\"image-picker__main-content\">\n <div class=\"image-picker__header-content\">\n <button class=\"image-picker__left-arrow\">\n <svg class=\"image-picker__svg-left\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M16.67 0l2.83 2.829-9.339 9.175 9.339 9.167-2.83 2.829-12.17-11.996z\" />\n </svg>\n </button>\n <a href=\"/content/images/products/nucleosomes/16-0415-dna-gel.jpeg\" target=\"_blank\"\n class=\"image-picker__main-image-link\"><img alt=\"16-0415-dna-gel\"\n src=\"/content/images/products/nucleosomes/16-0415-dna-gel.jpeg\"\n class=\"image-picker__main-image\" />\n <span class=\"image-picker__main-image-caption\">(Click to enlarge)</span></a>\n <button class=\"image-picker__right-arrow\">\n <svg class=\"image-picker__svg-right\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M7.33 24l-2.83-2.829 9.339-9.175-9.339-9.167 2.83-2.829 12.17 11.996z\" />\n </svg>\n </button>\n </div>\n <p>\n <span class=\"image-picker__span-content\"><strong>Figure 2: DNA gel data </strong><br />\n Heterotypic [H3K4me3 • H3K9,14,18ac] nucleosome resolved via native PAGE and stained with ethidium\n bromide to visualize DNA. Both lanes are from the same gel. <b>Lane 1</b>: Free DNA (EpiCypher <a\n href=\"/products/nucleosomes/nucleosome-assembly-601-sequence-dna-biotinylated\"\n target=\"_blank\">18-0005</a>; 75 ng). Free\n DNA is over 95% pure by densitometry. <b>Lane 2</b>: Intact heterotypic [H3K4me3 • H3K9,14,18ac]\n nucleosomes (400 ng).\n </span>\n </p>\n </div>\n <div class=\"image-picker__main-content\">\n <div class=\"image-picker__header-content\">\n <button class=\"image-picker__left-arrow\">\n <svg class=\"image-picker__svg-left\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M16.67 0l2.83 2.829-9.339 9.175 9.339 9.167-2.83 2.829-12.17-11.996z\" />\n </svg>\n </button>\n <a href=\"/content/images/products/nucleosomes/16-0415-luminex-multiplexed.jpeg\" target=\"_blank\"\n class=\"image-picker__main-image-link\">\n <img alt=\"16-0415-luminex-multiplexed\"\n src=\"/content/images/products/nucleosomes/16-0415-luminex-multiplexed.jpeg\"\n class=\"image-picker__main-image\" />\n <span class=\"image-picker__main-image-caption\">(Click to enlarge)</span>\n </a>\n <button class=\"image-picker__right-arrow\">\n <svg class=\"image-picker__svg-right\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M7.33 24l-2.83-2.829 9.339-9.175-9.339-9.167 2.83-2.829 12.17 11.996z\" />\n </svg>\n </button>\n </div>\n <p>\n <span class=\"image-picker__span-content\">\n <strong>Figure 3: Luminex multiplexed specificity profiling</strong><br />\n Heterotypic [H3K4me3 • H3K9,14,18ac] nucleosome was assessed using a Luminex® based approach. The\n panel comprises biotinylated designer nucleosomes individually coupled to color-coded Luminex\n MagPlex® beads. Histone antibody (EMD Millipore MAB3422), DNA antibody (EMD Millipore MAB030),\n H3K4me3 antibody (EpiCypher <a\n href=\"/products/antibodies/h3k4me3-antibody-snap-certified-for-cut-run-and-cut-tag\"\n target=\"_blank\">13-0060</a>), H3K9ac antibody (RevMAb 31-1054-00), H3K14ac antibody (ThermoFisher\n MA5-32814), and H3K18ac antibody (Cell Signaling Technology 13998) were added (x-axis), and a second\n layer of anti-IgG*Phycoerythrin (PE; BioLegend 406421 for anti-rabbit IgG or BioLegend 405307 for\n anti-mouse IgG) was used for detection. Data were generated using a Luminex FlexMAP 3D®. Histone and\n DNA antibodies bind nucleosomes in the panel equivalently, as expected. H3K4me3, H3K9ac, H3K14ac,\n and H3K18ac antibodies bind heterotypic [H3K4me3 • H3K9,14,18ac] nucleosomes at reduced strength in\n comparison to homotypic H3K4me3,K9,14,18ac nucleosomes (EpiCypher\n <a href=\"/products/nucleosomes/modified-designer-nucleosomes-dnucs/nucleosome-recombinant-human-h3k4me3-k9-14-18ac-dnuc-biotinylated\"\n target=\"_blank\">16-0335</a>).\n </span>\n </p>\n </div>\n </div>\n <aside class=\"image-picker__right\">\n <div class=\"image-picker__gallery\">\n <img alt=\"16-0415-protein-gel\" src=\"/content/images/products/nucleosomes/16-0415-protein-gel.jpeg\"\n width=\"200\" class=\"image-picker__side-image image-picker__side-image_active\" role=\"button\" />\n <img alt=\"16-0415-dna-gel\" src=\"/content/images/products/nucleosomes/16-0415-dna-gel.jpeg\"\n class=\"image-picker__side-image\" role=\"button\" />\n <img alt=\"16-0415-luminex-multiplexed\"\n src=\"/content/images/products/nucleosomes/16-0415-luminex-multiplexed.jpeg\"\n class=\"image-picker__side-image\" role=\"button\" />\n </div>\n </aside>\n </section>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <h3 class=\"sub-title1\">Technical Information</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <div class=\"product-tech-info\">\n <div class=\"product-tech-info__line-item\">\n <div class=\"product-tech-info__line-item-left\">\n <b>Storage</b>\n </div>\n <div class=\"product-tech-info__line-item-right\">\n Stable for six months at -80°C from date of receipt. For best\n results, aliquot and avoid freeze/thaws.\n </div>\n </div>\n <div class=\"product-tech-info__line-item\">\n <div class=\"product-tech-info__line-item-left\">\n <b>Formulation</b>\n </div>\n <div class=\"product-tech-info__line-item-right\">\n 10 mM Tris-HCl pH 7.5, 25 mM NaCl, 1 mM EDTA, 2 mM DTT, 20%\n glycerol (13.6 µg protein, 25 µg DNA + protein).\n </div>\n </div>\n </div>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <h3 class=\"sub-title1\">Application Notes</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <p>\n Heterotypic [H3K4me3 • H3K9,14,18ac] nucleosome is highly purified and suitable for a variety of\n applications, including use as a substrate in enzyme assays, high-throughput screening and inhibitor\n testing, chromatin binding studies, protein-protein interaction assays, structural studies, and in effector\n protein binding experiments. Trace amounts of TEV protease may be present (less than 5% of the preparation\n by densitometry,\n <b>Figure 1</b>). For a corresponding homotypic control, we recommend EpiCypher <a\n href=\"/products/nucleosomes/modified-designer-nucleosomes-dnucs/nucleosome-recombinant-human-h3k4me3-k9-14-18ac-dnuc-biotinylated\"\n target=\"_blank\">16-0335</a>.\n </p>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <h3 class=\"sub-title1\">Gene & Protein Information</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <div class=\"product-tech-info\">\n <div class=\"product-tech-info__line-item\">\n <div class=\"product-tech-info__line-item-left\">\n <b>UniProt ID</b>\n </div>\n <div class=\"product-tech-info__line-item-right\">\n H2A - P04908 (alt. names: H2A type 1-B/E, H2A.2, H2A/a, H2A/m)<br />\n H2B - O60814 (alt. names: H2B K, HIRA-interacting protein 1)<br />\n H3.2 - Q71DI3<br />\n H4 - P62805\n </div>\n </div>\n </div>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <h3 class=\"sub-title1\">References</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <strong>Background References:</strong>\n <br />\n [1] Valsakumar & Voigt. <em>Biochem. Soc. Trans.</em> (2024). PMID:\n <a href=\"https://pubmed.ncbi.nlm.nih.gov/38778762/\" target=\"_blank\"\n title=\"Nucleosomal asymmetry: a novel mechanism to regulate nucleosome function\">38778762</a><br />\n [2] Lowary & Widom <em>J. Mol. Biol.</em> (1998). PMID:\n <a href=\"https://pubmed.ncbi.nlm.nih.gov/9514715/\" target=\"_blank\"\n title=\"New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning\">9514715</a><br />\n [3] Jain et al. <em>eLife</em> (2023). PMID:\n <a href=\"https://pubmed.ncbi.nlm.nih.gov/37204295/\" target=\"_blank\"\n title=\"An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability\">37204295</a><br />\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <h3 class=\"sub-title1\">Documents & Resources</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <div class=\"product-documents\">\n <a href=\"/content/documents/tds/16-0415.pdf\" target=\"_blank\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0415 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n 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c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">Technical Datasheet</span>\n </a>\n </div>\n </div>\n </div>\n </div>\n </div>\n</div>","tags":[],"warranty":"","price":{"without_tax":{"formatted":"$525.00","value":525,"currency":"USD"},"tax_label":"Sales Tax"},"detail_messages":"","availability":"","page_title":"Heterotypic [H3K4me3 • H3K9,14,18ac] Recombinant Nucleosome, Biotinylated","cart_url":"https://www.epicypher.com/cart.php","max_purchase_quantity":0,"mpn":null,"upc":null,"options":[],"related_products":[{"id":768,"sku":"16-1316","name":"Nucleosome, Recombinant Human, H3K4me3 dNuc, Non‑biotinylated","url":"https://www.epicypher.com/products/nucleosomes/recombinant-nucleosomes-complete-list/nucleosome-recombinant-human-h3k4me3-dnuc-non-biotinylated","availability":"","rating":null,"brand":{"name":null},"category":["Nucleosomes/Recombinant Nucleosomes (Complete List)","Nucleosomes/Modified Designer Nucleosomes (dNucs™)"],"summary":"\n \n \n \n Description\n \n \n Mononucleosomes assembled from recombina","image":{"data":"https://cdn11.bigcommerce.com/s-y9o92/images/stencil/{:size}/products/768/966/nucleosome-recombinant-human-h3k4me3-dnuc-nonbiotinylated__98947.1645734558.jpg?c=2","alt":"Nucleosome, Recombinant Human, H3K4me3 dNuc, Non‑biotinylated"},"images":[{"data":"https://cdn11.bigcommerce.com/s-y9o92/images/stencil/{:size}/products/768/966/nucleosome-recombinant-human-h3k4me3-dnuc-nonbiotinylated__98947.1645734558.jpg?c=2","alt":"Nucleosome, Recombinant Human, H3K4me3 dNuc, Non‑biotinylated"}],"date_added":"16th Jul 2020","pre_order":false,"show_cart_action":true,"has_options":false,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":859,"name":"Pack Size","value":"50 µg"}],"num_reviews":null,"weight":{"formatted":"0.01 LBS","value":0.01},"demo":false,"add_to_cart_url":"https://www.epicypher.com/cart.php?action=add&product_id=768","price":{"without_tax":{"currency":"USD","formatted":"$575.00","value":575},"tax_label":"Sales Tax"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=768"},{"id":1164,"sku":"16-0408","name":"Heterotypic [H3 • H3K4me3] Recombinant Nucleosome, Biotinylated","url":"https://www.epicypher.com/products/nucleosomes/modified-designer-nucleosomes-dnucs/heterotypic-h3-h3k4me3-recombinant-nucleosome-biotinylated","availability":"","rating":null,"brand":{"name":null},"category":["Nucleosomes","Nucleosomes/Modified Designer Nucleosomes (dNucs™)"],"summary":"\n \n \n Species: Human\n \n \n Source: E. coli & synthetic DNA\n \n \n \n ","image":{"data":"https://cdn11.bigcommerce.com/s-y9o92/images/stencil/{:size}/products/1164/1236/Heterotypic_Nuc_white__46729.1723235178.png?c=2","alt":"Heterotypic [H3 • H3K4me3] Recombinant Nucleosome, Biotinylated"},"images":[{"data":"https://cdn11.bigcommerce.com/s-y9o92/images/stencil/{:size}/products/1164/1236/Heterotypic_Nuc_white__46729.1723235178.png?c=2","alt":"Heterotypic [H3 • H3K4me3] Recombinant Nucleosome, Biotinylated"}],"date_added":"9th Aug 2024","pre_order":false,"show_cart_action":true,"has_options":false,"stock_level":null,"low_stock_level":null,"qty_in_cart":0,"custom_fields":[{"id":1329,"name":"Pack Size","value":"25 µg"}],"num_reviews":null,"weight":{"formatted":"0.00 LBS","value":0},"demo":false,"add_to_cart_url":"https://www.epicypher.com/cart.php?action=add&product_id=1164","price":{"without_tax":{"currency":"USD","formatted":"$525.00","value":525},"tax_label":"Sales 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Pack Size: 25 µg
![Heterotypic [H3 • H3K4me3] Recombinant Nucleosome, Biotinylated](https://cdn11.bigcommerce.com/s-y9o92/images/stencil/500x500/products/1164/1236/Heterotypic_Nuc_white__46729.1723235178.png?c=2)
![Heterotypic [H3 • H3K14ac] Recombinant Nucleosome, Biotinylated](https://cdn11.bigcommerce.com/s-y9o92/images/stencil/500x500/products/1165/1237/Heterotypic_Nuc_white__35995.1723235305.png?c=2)
![Heterotypic [H3 • H3K4me3,K14ac] Recombinant Nucleosome, Biotinylated](https://cdn11.bigcommerce.com/s-y9o92/images/stencil/500x500/products/1166/1238/Heterotypic_Nuc_white__67835.1723235454.png?c=2)
![Heterotypic [H3K4me3 • H3K14ac] Recombinant Nucleosome, Biotinylated](https://cdn11.bigcommerce.com/s-y9o92/images/stencil/500x500/products/1167/1239/Heterotypic_Nuc_white__99511.1723235561.png?c=2)
