Boldly Going Where No Nucleosome Has Gone Before
In the past decade, scientists have uncovered more than 100 unique histone post-translational modif…
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Oh, the Places SNAP-ChIP® Will Go : Acylation and Combinatorial PTMs
As the quality and specificity of antibodies is an ongoing issue in biomedical research1, 2,…
dCypher™ Nucleosome Panels: Unparalleled Diversity for Rapid Histone PTM Profiling
Epigenetics is one of the fastest-growing areas of academic and pharmaceutical research, wit…
EpiDyne®: Exploring Chromatin Remodeling Substrates with Nucleosomes
Nucleosomes are the fundamental repeating units of chromatin, comprised of a histone octamer wrapped by ~147bp DNA. A c…
Peptide or Nucleosome? dCypher™ Reveals the Optimal Substrate for Histone PTM Analyses
Histone ‘reader’ proteins contain evolutionarily conserved domains that bind to specific histone post-tra…
Why are designer nucleosomes so important for epigenetics research?
Nucleosome substrates are emerging tools for the in vitro study of chromatin epigenetic regulation, with applications from basic chromatin…