Recombinant Histones

Recombinant histone proteins are the building block of nucleosomes, and an essential reagent in chromatin research. EpiCypher offers highly pure recombinant histone proteins, including canonical histones (H2A, H2B, H3 and H4) and histone variants, such as H2AZ.1, H2AZ.2 and H2AX.

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Applications of EpiCypher recombinant histones

Applied as control in mass spectrometry studies (Fouque et al. 2022)
Assembly of CENP-A variant nucleosomes for microscopy (Stumme-Diers et al. 2019)
Substrate to study arginine methylation by PRMT enzymes (Fulton et al. 2021)

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Need help with nucleosome assembly? Check out our custom nucleosome development services
EpiCypher nucleosomes are rigorously validated to deliver highly pure substrates. Read our blog for more info
Curious about nucleosome applications in epigenetics research? See the brochure