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Recombinant Nucleosomes (rNucs)
Recombinant Nucleosomes (rNucs) are human recombinant nucleosomes comprised of histone proteins made in E. coli wrapped with fully synthetic Widom 601 DNA. As the nucleosome is the true physiologic substrate for many histone modifying enzyme, these are excellent substrates for enzyme screening assays.
Nucleosomes: Nature’s preferred chromatin substrate
EpiCypher has an extensive library of recombinant nucleosomes, including
- rNucs wrapped with hemi-methylated and methylated DNA templates
- Unmodified rNucs, which can be used as controls in chromatin assays
- rNucs assembled with histone variants (i.e. H2AZ)
Learn more:
- Recombinant Nucleosome Brochure
- Using nucleosomes to study chromatin readers / PTM binding specificity?See our dCypher™ Tech Note
- Nucleosomes vs. modified histone peptides : Which is best? Read our Blog for more info!
- How do we quantify our nucleosomes? See our Nucleosome Quantification Method
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Mononucleosomes (H2AX), Human Recombinant
SKU: 16-1013
Mononucleosomes (H2AX), Human Recombinant Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2AX, H2B, H3 and H4. Accession numbers: H2A...
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Mononucleosomes (H3.1ΔN32), Recombinant Human
SKU: 16-1016
Recombinant mononucleosomes (H3.1ΔN32) consist of 147 base pairs of
DNA wrapped around an octamer core of histone proteins (two each of
H2A, H2B, H3.1, and H4) to form a nucleo...
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