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Mutant Nucleosomes
Histone mutations cause distinct changes in nucleosome structure, chromatin accessibility and gene expression, and are linked to numerous disease states. This research has also revealed the importance of considering the entire nucleosome structure in chromatin interactions, as several of these mutations occur within the nucleosome core and modulate PTM crosstalk and multivalent binding mechanisms. EpiCypher offers a unique collection of Mutant Nucleosomes (Mutant Nucs) providing defined substrates for binding assays, drug research, and more.
Substrate Types and Applications
- Oncogenic Nucleosomes (e.g. H3.3K27M, H3.3G34R)
- Acidic Patch Mutant Nucleosomes (e.g. H2AE61A, H2AE92K)
- Study impact of mutant histones on protein binding / enzymatic function
- Useful for drug / inhibitor development and HTS
Learn more:
- Recombinant Nucleosomes Brochure: Overview of all our nucleosome products
- Acidic Patch Blog: All you need to know about the nucleosome acidic patch
- How do we quantify our nucleosomes? See our Nucleosome Quantification Method
Shop related products and services:
Acidic Patch Mutant H2BE105A,E113A Recombinant Nucleosome with Linker DNA, Biotinylated
SKU: 16-2031
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