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Modified Designer Nucleosomes (dNucs™)
EpiCypher dNucs™ are semi-synthetic recombinant nucleosomes, containing one (or more) histone PTMs. Nucleosomes are the natural target of chromatin readers and modifying enzymes, and thus provide a superior substrate for epigenetic enzymes and interactor proteins.
dNuc substrates enable cutting-edge chromatin research
EpiCypher has an extensive library of >70 uniquely modified dNucs, useful for:
- dCypher™: Discovery platform to study chromatin readers and enzymes
- AlphaNuc™: HTS assays for inhibitor development
- EpiDyne®: Quantitative chromatin remodeling assays
- Interested? Use the promo code "4for3" to buy any 3 full size dNucs and get one free!
Learn more:
- Recombinant Nucleosomes Brochure
- Using dNucs to study chromatin readers or PTM binding specificity? See our dCypher Tech Note!
- Interested in inhibitor screening? See our Tech Note AlphaNuc HTS assays
- How do we quantify our nucleosomes? See our Nucleosome Quantification Method
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