SKU: 15-0047
{"url":"https://www.epicypher.com/products/recombinant-proteins/histone-binding-domains/brd4-bromodomain-2-his-tagged","add_this":[{"service":"facebook","annotation":""},{"service":"email","annotation":""},{"service":"print","annotation":""},{"service":"twitter","annotation":""},{"service":"linkedin","annotation":""}],"gtin":null,"options":[],"id":208,"bulk_discount_rates":[],"can_purchase":true,"meta_description":"Recombinant Human BRD4 Bromodomain 2 for Acetyl-Lysine Binding Protein and Substrate Recognition Experiments","category":["Recombinant Proteins/Histone Binding Domains","Recombinant Proteins/Histone Binding Domains/Bromodomain Proteins"],"AddThisServiceButtonMeta":"","main_image":{"data":"https://cdn11.bigcommerce.com/s-y9o92/images/stencil/{:size}/products/208/984/3vId-MiA__35885.1646104221.png?c=2","alt":"BRD4 Bromodomain 2, His-tagged"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=208","shipping":{"calculated":true},"num_reviews":0,"weight":"0.01 LBS","custom_fields":[{"id":"1064","name":"Pack Size","value":"100 μg"},{"id":"1065","name":"Internal Comment","value":"Bulk in LG"}],"sku":"15-0047","description":"<div><table width=\"100%\" border=\"0\" cellspacing=\"2\" cellpadding=\"2\"> <tbody> <tr valign=\"top\"> <td> <table width=\"400\" border=\"0\" cellspacing=\"1\" cellpadding=\"1\"> <tbody> <tr> <td> <table width=\"100%\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\"> <tbody> <tr> <td align=\"left\" valign=\"top\"><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 10pt; \" class=\"Apple-style-span\"><b>Type: </b>Bromodomain</span></span> </td> <td align=\"left\" valign=\"top\"><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 10pt; \" class=\"Apple-style-span\"><b>Host: </b><em>E. coli</em></span></span> </td> </tr> <tr> <td align=\"left\" valign=\"top\"><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 10pt; \" class=\"Apple-style-span\"><b>Mol Wgt.: </b>16 kDa</span></span> </td> <td align=\"left\" valign=\"top\"><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 10pt; \" class=\"Apple-style-span\"><b>Epitope Tag: </b>His</span></span> </td> </tr> </tbody> </table> </td> </tr> <tr> <td valign=\"top\"><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 12pt; \" class=\"Apple-style-span\"><br /> <b><span class=\"Apple-style-span\" style=\"font-family: Arial; \"><span class=\"Apple-style-span\" style=\"font-size: 12pt; \"><b>Recombinant </b></span></span>BRD4 Bromodomain 2, His-tagged Description:</b> Recombinant human BRD4 Bromodomain 2, His-tagged (HUNK1, accession number O60885, amino acids 341 to 470) containing an N-terminal 6xHis tag, expressed in <em>E. coli</em>. BRD4 is a member of the BET sub-family of bromodomain-containing proteins, which also includes BRD2, BRD3 and BRDT. BET proteins have two bromodomains and an ET domain C-terminal to the second bromodomain. BRD4 serves as a cofactor for Myc and is crucial to Myc's role in acute myeloid leukemia. Inhibition of BRD4 binding suppresses Myc activity and leads to differentiation of AML cells and elimination of AML stem cells.<br /> <br /> </span></span> </td> </tr> <tr> <td valign=\"top\"><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 12pt; \" class=\"Apple-style-span\"><b><span class=\"Apple-style-span\" style=\"font-family: Arial; \"><span class=\"Apple-style-span\" style=\"font-size: 12pt; \"><b>Recombinant</b></span></span> BRD4 Bromodomain 2, His-tagged Formulation:</b> Recombinant 6xHis-tagged protein at 1 mg/ml in 20 mM Tris-HCl pH 8.0, 200 mM NaCl, 1 mM DTT, 20% glycerol.<br /> <br /> </span></span> </td> </tr> <tr> <td valign=\"top\"><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 12pt; \" class=\"Apple-style-span\"><b><span class=\"Apple-style-span\" style=\"font-family: Arial; \"><span class=\"Apple-style-span\" style=\"font-size: 12pt; \"><b>Recombinant </b></span></span>BRD4 Bromodomain 2, His-tagged Storage and Stability:</b> Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.<br /> <br /> </span></span> </td> </tr> <tr> <td valign=\"top\"><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 12pt; \" class=\"Apple-style-span\"><b><span class=\"Apple-style-span\" style=\"font-family: Arial; \"><span class=\"Apple-style-span\" style=\"font-size: 12pt; \"><b>Recombinant </b></span></span>BRD4 Bromodomain 2, His-tagged Application Notes:</b> Recombinant BRD4 Bromodomain 2, His-tagged is useful for protein binding and screening experiments examining acetylated protein substrates.<br /> <br /> </span></span> </td> </tr> <tr> <td valign=\"top\"> <p><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 12pt; \" class=\"Apple-style-span\"><b><span class=\"Apple-style-span\" style=\"font-family: Arial; \"><span class=\"Apple-style-span\" style=\"font-size: 12pt; \"><b>Recombinant </b></span></span>BRD4 Bromodomain 2, His-tagged References:</b><br /> <br /> </span></span><br /> </p> </td> </tr> <tr> <td valign=\"top\"><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 12pt; \" class=\"Apple-style-span\">View technical datasheet for this product. <a href=\"/content/documents/tds/15-0047.pdf\" target=\"_new\"> <img src=\"/content/documents/tds/icon.png\" alt=\"15-0047 Datasheet\" width=\"30\" height=\"40\" /></a></span></span> </td> </tr> </tbody> </table> </td> <td> <table width=\"100%\" border=\"0\" cellspacing=\"3\" cellpadding=\"3\"> <tbody> <tr> <td align=\"center\"><a href=\"/content/images/products/proteins/15_0047_gel_web.jpg\" target=\"_new\"> <img src=\"/content/images/products/proteins/15_0047_gel_web.jpg\" alt=\"15-0047 Protein Gel Data\" width=\"165\" height=\"275\" /></a> </td> </tr> <tr> <td align=\"left\" valign=\"top\"> <p><span style=\"font-family: Arial; \" class=\"Apple-style-span\"><span style=\"font-size: 10pt; \" class=\"Apple-style-span\"><strong>Protein Gel Data:</strong> BRD4 Bromodomain 2, His-tagged (1 µg) was run on a PAGE gel and stained with Coomassie blue. The migration and molecular weight of the protein standards are indicated.<br /> <strong>(Click image to enlarge) </strong></span></span></p> <p></p> </td> </tr> </tbody> </table> </td> </tr> </tbody></table></div>","tags":[],"warranty":"","price":{"without_tax":{"formatted":"$325.00","value":325,"currency":"USD"},"tax_label":"Sales Tax"},"detail_messages":"","availability":"","page_title":"Recombinant Human BRD4 Bromodomain 2, His-tagged | For Acetyl-Lysine Binding Protein and Substrate Recognition Experiments","cart_url":"https://www.epicypher.com/cart.php","max_purchase_quantity":0,"mpn":null,"upc":"100 µg","shipping_messages":[],"rating":0,"meta_keywords":"Recombinant Human acetyl-lysine binding protein, brd 4, brd, brd4, brd-4, bromodomain containing, bromodomain, bromodomain-containing, cap, hunk1, hunki, mcap, histone binding domain, lysine, histone acetylation, acetylation, histone-binding, bromodomain containing, bromodomain, bromodomain-containing, histone binding domain, lysine, histone acetylation, acetylation","show_quantity_input":1,"title":"BRD4 Bromodomain 2, His-tagged","gift_wrapping_available":false,"min_purchase_quantity":0,"customizations":[],"images":[{"data":"https://cdn11.bigcommerce.com/s-y9o92/images/stencil/{:size}/products/208/984/3vId-MiA__35885.1646104221.png?c=2","alt":"BRD4 Bromodomain 2, His-tagged"},{"data":"https://cdn11.bigcommerce.com/s-y9o92/images/stencil/{:size}/products/208/124/Me_Peptide_Binding-1__52520.1444238478.jpg?c=2","alt":"BRD4 Bromodomain 2, His-tagged"}]}
Pack Size: 100 μg
